- Cancer Associated Fibroblast (CAF)
- Fibroblast cells associated with the tumor microenvironment that are metabolically distinct from healthy fibroblast cells. CAFs secrete tumor growth factors and suppress the body’s immune response to the tumor.
- Fibroblast Activation Protein (FAP)
- A cell-surface protein that is highly expressed in cancer associated fibroblasts and cancer cells.
- A radioactive isotope of Gallium, which is a gamma particle emitting radionuclide. Gallium-68 is a commonly used radionuclide in diagnostic imaging tools in healthcare.
- A radioactive isotope of Lutetium, which is a beta particle emitting radionuclide.
- Short for radioactive nuclide, a radionuclide is an unstable atom that emits radioactive particles in the form of alpha, beta, or gamma particles.
- The combination of using one radionuclide to image tumors and a second radionuclide to treat tumors.
- Tumor Microenvironment (TME)
- The tumor microenvironment is the environment surrounding the mass of cancerous tumor cells, including blood vessels, immune cells, cancer associated fibroblasts, signaling molecules and the extracellular matrix. The tumor is supported by its surrounding microenvironment.